Mauna Lani

The first generic antidepressant Lexapro is approved

The FDA has approved the first generic popular antidepressant Lexapro (escitalopram). As well as branded drugs, generic product approved for the treatment of generalized anxiety and depression in adults syndrome. Escitalopram was approved in 2002, is produced and distributed by the American company Forest Laboratories Inc. together with the Danish pharmaceutical company Lundbeck. The generic form is manufactured by Teva Pharmaceutical Industries / IVAX Pharmaceuticals, American manufacturers of many other generic drugs. For six months, the company will be the sole producer of generic forms of the drug in doses of 5, 10 and 20 milligrams.

Depression causes a constant feeling of sadness, anger and helplessness, which may adversely affect the daily activities of a person, that is, work, sleep and study, and also reduces the interest in things that used to cause pleasure. According to the Center for Control and Prevention of morbidity around 9% of the adult population suffer from some form of depression that lasts for two weeks or more. Most depression is common in women than in men.

The syndrome of generalized anxiety is a concern, even when there is no reason for concern. Since it develops slowly, beginning as a teenager, eventually it can become a serious enough problem that could prevent the usual daily work and life. People with generalized anxiety syndrome often have trouble concentrating and sleeping. Observed symptoms such as headache, tremors and problems with swallowing. According to the National Institute of Mental Health annually at about 3% of adults diagnosed with generalized anxiety syndrome.

"These psychiatric disorders can interfere with a person to conduct his usual life", - he said in a press release by Janet Woodcock, MD, director of the Center for Research and Assessment of drugs the Office of the Food and Drug US drugs. "This drug is widely used by patients who need to deal with these problems for a long time, so for them it is so important to have affordable treatment options."

Escitalopram is a selective serotonin reuptake inhibitor, an antidepressant that works by regulating the chemical messenger serotonin. Common side effects include insomnia, ejaculation disorder, nausea, sweating, fatigue and drowsiness, and decreased libido (decreased libido). As with all other antidepressants, escitalopram is supplied in packages with a black box warning, which warns of an increased risk of suicidal behavior in children, adolescents and young people in the initial phase of treatment. However, these risks in patients older than 24 years were observed, and in patients older than 65 years reduces the risk.

Escitalopram belongs to selective blockers reverse zahavata seronina (SSRI). This drug is used to treat major depressive disorder in children and adults, generalized anxiety disorder, obsessive - compulsive disorder, post-traumatic stress syndrome disorder, cataplexy, and in psychosis, developed on the background of dementia. Like citalopram, escitalopram and consist of the enantiomers S and R). These drugs increase serotonin levels in a few hours, but the effect of its own as the antidepressant escitalopram develops within a few weeks. It is noted that some patients on lower doses polytherapy escitalopram may be more effective than monotherapy with this drug at high doses.

             For security reasons, escitalopram treatment is recommended to make an electrocardiogram (prolongation QTs segment). , Especially in patients with a family burdened QTs extension, with a propensity for cardiac arrhythmia after acute myocardial infarction with signs of heart failure.

            Of the side effects of the drug should be noted nausea, sleep disturbance, fatigue, somnolence, hyperhidrosis, decreased libido, delayed ejaculation and anorgasmia. Of the dangerous complications of therapy with escitalopram mark besides the QT prolongation, serotonin syndrome, the progression of angle-closure glaucoma, lowering the seizure threshold (rarely), activation of mania and suicidal thoughts, especially during the few months of therapy. Very rarely it marked hyponatremia and bleeding. The drug has no effect on body weight. In the presence of drug side effects, reduce the dose and ted it more slowly, you must also be aware of the possibility of withdrawal symptoms after discontinuation of escitalopram.

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